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On one hand, 1,25(OH)D can attenuate VDR ubiquitination and delay its degradation ( Notably, renal transplantation provides direct evidence supporting the reversibility of vitamin D metabolic impairment

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Similarly, maternal exposure to inflammatory insults during pregnancy leads to elevated IL-6 levels in the systemic circulation, which induces IL-6R expression in fetal intestinal epithelial stem cells, this inflammatory imprint persists into adulthood, conferring increased resistance to intestinal infections in the offspring ( in vivo models